Training in large bowel cancer surgery: observations from three prospective regional United Kingdom audits.

Association of Long Term Antibiotic Use and Diagnosis of Chronic Disease

Background: There has recently been increasing interest in the role of the human microbiome in disease. Antibiotic use is known to disrupt the intestinal microbial environment and cause acute disease, for example pseudomembranous colitis. This study aimed to investigate the hypothesis that long-term antibiotic use is associated with the development of chronic diseases, i.e., Asthma, Rheumatoid ...

Re-organising Junior Doctors During the COVID-19 Outbreak: A Single Centre Experience in the United Kingdom

CLINICAL TRIALS AND OBSERVATIONS Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993

1University College London, London, United Kingdom; 2Rambam Medical Center and Technicon, Israel Institute of Technology, Haifa, Israel; 3Clinical Trial Service Unit, Oxford, United Kingdom; 4Northern Institute for Cancer Research, Newcastle University, Newcastle, United Kingdom; 5Bristol Haematology and Oncology Centre, Bristol, United Kingdom; 6Nottingham University, Nottingham, United Kingdo...

Public Spending on Health Services and Policy Research in Canada: A Reflection on Thakkar and Sullivan; Comment on “Public Spending on Health Service and Policy Research in Canada, the United Kingdom, and the United States: A Modest Proposal”

Vidhi Thakkar and Terrence Sullivan have done a careful and thought-provoking job in trying to establish comparable estimates of public spending on health services and policy research (HSPR) in Canada, the United Kingdom and the United States. Their main recommendation is a call for an international collaboration to develop common terms and categories of HSPR. This paper raises two additional q...

CLINICAL TRIALS AND OBSERVATIONS The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis

1Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom; 2Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom; 3St James’s University Hospital, Leeds, United Kingdom; 4Nottingham University Hospital, Nottingham, United Kingdom; 5Royal Devon and Exeter Hospital, Exeter, United Kingdom; 6Western General Hospital, Edinburgh, United Kingdom; 7University o...